端粒酶逆转录酶基因rs10069690变异与癌症风险的关联:更新的元分析
Chao Zhou1, Yunke Yang2, Lu Shen2
1Department of Thoracic Surgery, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
BMC cancer
|August 27, 2024
概括
TERT rs10069690变种增加了癌症风险,特别是在欧洲和亚洲人群中. 这一遗传因素与几个固体瘤的风险增加有关,包括乳腺癌,卵巢癌和肺癌.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 端粒维护对细胞不死亡至关重要,在癌症中经常有调节障碍.
- 端粒酶激活由端粒酶逆转录酶 (TERT) 基因调节,是许多癌症的标志.
- TERT rs10069690 (C>T) 单核酸多态性已被研究其与癌症易感性的关联,但结果不一致.
研究的目的:
- 进行全面的元分析,以澄清TERT rs10069690变体与整体癌症易感性之间的关联.
- 调查这种变异对特定癌症类型风险和不同族裔群体的影响.
主要方法:
- 在主要数据库 (PubMed,EMbase,MEDLINE,Cochrane Library) 进行了系统的文献搜索,截至2024年4月30日.
- 分析包括55项研究,包括334,196名癌症患者和741,187名对照.
- 使用STATA软件 (11.0版本) 进行统计分析.
主要成果:
- TERT rs10069690变体与癌症风险增加有显著关联 (OR=1.10,95% CI:1.07-1.13,P<0.001),特别是在欧洲和亚洲人群中.
- 乳腺,卵巢,肺,甲状腺,胃和细胞癌的风险增加.
- 相反,该变体与肝细胞癌,前列腺癌和胰腺癌的风险降低有关,并且与固体瘤有显著联系,但与血液性恶性瘤无关.
结论:
- TERT rs10069690变种是癌症发展的重要危险因素.
- 这种基因变异对癌症风险的影响取决于特定的癌症类型和种族背景.
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