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不同白细胞计数和表观遗传时钟:双向的门德尔随机化研究

Manli Sun¹, Huan Yang¹, Yang Hu²

¹Drug Clinical Trail Center, The Second Hospital of Heilongjiang Province, 209 Jiangdu Street, Harbin, China.

Clinical epigenetics

|August 27, 2024

概括

较低的淋巴细胞和较高的中性粒细胞数量加速表观遗传衰老. 白细胞计数因果影响表观遗传时钟,影响PhenoAge,GrimAge和HannumAge,但不是相反.

科学领域:

遗传学是一个遗传学.
免疫学免疫学免疫学
衰老研究研究衰老研究

背景情况:

人的衰老和白细胞 (WBC) 计数是受遗传学影响的复杂特征.
表观遗传时钟预测时间年龄,但它们与白血球计数的双向关系未得到充分探索.

研究的目的:

为了研究表观遗传钟和白细胞计数之间的双向因果关系.
为了确定特定的WBC类型是否影响表观遗传衰老加速.

主要方法:

孟德尔随机化 (MR) 分析使用来自四个表观遗传钟和血细胞联盟的总结统计数据.
采用随机效应逆变量加权方法和多变量MR.

主要成果:

淋巴细胞数量的减少加速了PhenoAge,GrimAge和HannumAge.
增加的中性粒细胞数量增加了PhenoAge,GrimAge和HannumAge.
没有发现表观遗传钟对整体白细胞计数的显著因果影响.

结论:

淋巴细胞和中性粒细胞的数量对加速表观遗传衰老 (PhenoAge,GrimAge,HannumAge) 有独立的因果关系.
白细胞在影响表观遗传时钟方面发挥着至关重要的作用.
免疫参数对于解释表观遗传年龄很重要.

关键词:

衰老的衰老衰老的衰老表观遗传年龄加速淋巴细胞细胞的细胞是淋巴细胞.门德尔的随机化 (MR)中性细胞细胞的中性细胞.白细胞是白细胞的组成部分.

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