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肠道微生物群与老年人肉症或其定义参数之间的关联:系统性审查

Laurence Lapauw¹, Aurélie Rutten², Jolan Dupont^1,3

¹Department of Public Health and Primary Care, Division of Gerontology and Geriatrics, KU Leuven, Leuven, Belgium.

Journal of cachexia, sarcopenia and muscle

|August 28, 2024

概括

改变的肠道微生物群 (GM) 与肉症有关. 与健康成年人相比,患有sarcopenia的个体表现出减少的转基因多样性和独特的微生物组成,这表明潜在的肠-肌肉轴连接.

科学领域:

微生物组研究的研究.
老年学是一门学科.
肌肉生理学肌肉生理学

背景情况:

标志着肌肉质量损失和功能衰退的萨尔科佩尼亚是老年人群日益关注的问题.
肠-肌肉轴提出了肠道微生物群和骨肌肉之间的双向通信途径.
改变肠道微生物群的组成可能会影响肉症的发展和进展.

研究的目的:

系统地审查和比较肠道微生物群 (GM) 的人与肉症与那些保存肌肉状态.
为了调查沙尔科佩尼亚定义参数与转基因组合或多样性之间的关联.
为了确定是否存在 Sarcopenia 独特的转基因签名.

主要方法:

按照PRISMA指南进行系统审查,注册在PROSPERO.
在PubMed,科学网,Embase,临床试验.gov和Cochrane图书馆搜索到2023年7月.
包括32项观察性研究 (N=10,781,年龄≥50岁) 分析转基因和肉病或其参数.

主要成果:

在转基因种类和肉类,肌肉质量,力量和身体表现之间发现了显著的关联,尽管方向异构.
肠道微生物群的β-多样性在sarcopenic和非sarcopenic组之间有所不同.
阿尔法多样性 (丰富和多样性) 在患有肉类或肌肉质量低的个体中较低,与肌肉质量和力量有积极的相关性.

结论:

患有肉症和低肌肉参数的个体表现出不那么多样化的肠道微生物群和独特的转基因成分.
虽然存在关联,但异质性和研究设计排除了因果结论.
需要使用标准化方法进行进一步的纵向研究,以确认特定于肉病的转基因特征.

关键词:

我们的肠道微生物群.肌肉质量肌肉质量肌肉质量肌肉的力量肌肉的力量年龄较大的成年人.身体的表现身体的表现萨尔科佩尼亚是什么意思萨尔科佩尼亚

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