相关的高血症和甲状腺功能障碍症:一个系统的审查和元分析
L Vandermeulen1, L Van Melkebeke2, P Sienaert1,3
1University Psychiatric Center KU Leuven, KU Leuven, Leuven, Belgium.
概括
的使用显著增加了类甲状腺功能障碍的风险,影响大约4%的患者. 这种状况的特点是高和PTH水平,可以通过手术或药物治疗.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 是一种常见的情绪稳定剂.
- 甲状腺功能障碍是疗法的潜在并发症.
- 关于这种关联的现有文献需要综合.
研究的目的:
- 系统地审查和总结人类关于和甲状腺功能障碍症的文献.
- 通过元分析来确定相关高血症 (LAHca) 的患病率.
主要方法:
- 使用PRISMA指导方针进行系统的文献搜索 (MEDLINE,科学网络,Embase,科克兰图书馆).
- 进行元分析以计算LAHca的综合流行率.
- 对和副甲状腺激素 (PTH) 水平的分析.
主要成果:
- 总的LAHca患病率为3.17% (总) 和4.23% (电离).
- 的使用与和PTH水平升高以及甲状腺功能障碍症发病率增加有关.
- 在LAH中多腺体疾病的患病率为51.28%.
结论:
- 治疗会增加甲状腺功能障碍症的风险,在一般人群中,综合患病率约为4%与0.5%.
- 副甲状腺手术和cinacalcet是对LAH的有效治疗方法.
- 关于停止使用来解决LAH的证据是事和矛盾的.
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