人类和动物肠道共生物和益生菌与现代生物安全挑战:问题和前景
V M Chernov1, O A Chernova1, M V Trushin2
1Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Kazan, Russia.
Archives of Razi Institute
|August 28, 2024
概括
了解肠道微生物群和益生菌对于宿主健康至关重要. 新的多主题数据揭示了潜在的风险,强调了对具有GRAS地位的益生菌进行标准化安全评估的必要性.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
背景情况:
- 肠道微生物群在宿主生理学和免疫系统激活中发挥着关键作用.
- 益生菌,包括那些具有一般公认的安全 (GRAS) 状态的益生菌,被广泛使用,但它们与宿主的复杂相互作用尚未完全理解.
- 高分辨率的方法,如多omics正在彻底改变我们对微生物与宿主相互作用的理解.
研究的目的:
- 为了解决缺乏对益生菌进行标准化安全评估的问题.
- 调查益生菌与宿主相互作用背后的分子机制.
- 开发用于控制细菌毒性和确保益生菌安全的策略.
主要方法:
- 用于高分辨率分析的多主题技术.
- 研究微生物和真核细胞之间的分子相互作用.
- 开发益生菌的标准化安全评估协议.
主要成果:
- 数据显示,一些广泛使用的益生菌可以诱导对细菌生长有益的宿主过程,挑战以前的假设.
- 我们对益生菌生命逻辑和相互作用机制的知识存在重大差距.
- 目前对GRAS益生菌的安全性评估协议是不够的.
结论:
- 迫切需要对益生菌进行全面的研究,并对其安全性评估进行标准化.
- 了解微生物与真核生物相互作用的分子基础对于实际应用至关重要.
- 标准化的安全评估对于在医学,农业和生物技术中负责任地使用益生菌至关重要.
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