胰腺癌患者营养和炎症标志物的表现
Jie-Nan Lu1, Lu-Sha Zhou1, Shuai Zhang1
1Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
World journal of clinical oncology
|August 28, 2024
概括
手术前的炎症和营养标志物,如预后营养指数 (PNI),可以预测胰腺癌的恢复和存活率. 较高的PNI表明更好的结果,而系统性免疫炎症指数 (SII) 预测延迟恢复.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物标志物研究 生物标志物研究
背景情况:
- 系统性炎症和营养状况显著影响癌症的进展.
- 这些因素可能导致手术后的恢复延迟.
研究的目的:
- 评估炎症和营养标志物,以预测胰腺癌 (PC) 患者的预后和术后恢复.
- 评估PNI,SII,NLR和PLR等生物标志物的临床实用性.
主要方法:
- 在446名接受手术切除的PC患者进行了回顾性观察队列研究.
- 对七个手术前生物标志物的分析:白蛋白与血球蛋白比率,PNI,SII,NLR,PLR,NRI和老年NRI.
- 统计分析包括多变量逻辑回归和考克斯回归.
主要成果:
- 较高的PNI和较低的SII,NLR和PLR值与早期的术后出院有关.
- SII被确定为延迟外科康复的独立风险因素.
- PNI成为整体存活率 (OS) 和无复发存活率 (RFS) 的最强的预后标志物.
结论:
- 手术前的炎症和营养生物标志物可以预测短期的手术恢复.
- 这些生物标志物对于预测胰腺癌患者的长期结果非常有价值.
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