与免疫检查点抑制剂诱导的免疫相关不良事件相关的生物标志物
An-Jie Guo1, Qing-Yuan Deng1, Pan Dong1
1School of Life Sciences, Chongqing University, Chongqing 400044, China.
World journal of clinical oncology
|August 28, 2024
概括
免疫检查点抑制剂 (ICI) 引起与免疫相关的不良事件 (irAEs). 本综述探讨了用于预测和诊断irAEs的生物标志物,这些生物标志物对于有效的癌症免疫治疗至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症免疫疗法.
- 与免疫相关的不良事件 (irAEs) 是常见的,并且难以诊断.
- 目前的诊断方法难以将IREs与其他疾病区分开来.
研究的目的:
- 审查现有的免疫相关不良事件 (irAEs) 的生物标志物.
- 探索新的生物标志物发现方法,用于irAEs.
- 提高对irAEs机制的理解,以改善预测和诊断.
主要方法:
- 对irAEs生物标志物的综合文献综述.
- 分析包括机器学习,单细胞RNA测序,多组学和肠道微生物群分析在内的创新方法.
- 对irAEs机制的检查.
主要成果:
- 现有研究为识别irAEs生物标志物提供了基础.
- 新兴技术为发现强大而精确的irAEs生物标志物提供了潜力.
- 了解irAEs机制是开发预测和诊断工具的关键.
结论:
- 迫切需要可靠的生物标志物来预测和诊断irAEs.
- 像多组学和机器学习这样的先进技术对生物标志物发现有希望.
- 对irAEs机制的进一步研究将改善ICI治疗患者的治疗结果.
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