使用PaperSpray与高分辨率质谱仪接口的新型精神活性物质的快速选和识别
Joseph Kennedy1, Kevin G Shanks2, Kristine Van Natta3
1Prosolia Inc., Indianapolis, IN, United States.
Clinical mass spectrometry (Del Mar, Calif.)
|August 28, 2024
概括
法医科学家现在可以快速识别新型精神活性物质 (NPS),如合成丁和大麻素. 一种新的自动化PaperSpray®电离技术与高分辨率精确质谱 (HRAM) 结合,简化了无需参考标准的药物分析.
科学领域:
- 法医化学 法医化学
- 分析化学 分析化学
- 质谱测量质量谱测量
背景情况:
- 设计药物,包括合成的甲基和大麻素,经常被滥用.
- 当前的分析方法往往缺乏光谱库和简单的样本引入技术.
- 新型精神活性物质 (NPS) 在法医识别方面带来了挑战.
研究的目的:
- 提出一种简单,快速和自动化的方法来检测和识别设计药物.
- 克服目前基于质谱的药物分析的局限性.
- 为了在不需要参考标准的情况下识别NPS.
主要方法:
- 使用了PaperSpray®电离,这是一种用于样本分析的自动化技术.
- 使用高分辨率精确质谱仪 (HRAM) 进行敏感检测.
- 在普通溶剂中溶解或提取的加工样品直接放在PaperSpray®弹上.
主要成果:
- 实现了各种设计药物矩阵的快速分析,包括粉末和植物材料.
- 证明了PaperSpray®对高通量样品引入的电离的有效性.
- 通过PaperSpray®-HRAM联合方法成功识别了新物质,无需染色学或先前净化.
结论:
- 结合PaperSpray®电离和HRAM,为NPS的法医识别提供了一个强大而简单的工具.
- 这种自动化技术简化了设计药物的分析,解决了现有方法的局限性.
- 该方法有助于识别新物质,即使没有参考标准,帮助执法部门和法医科学家.
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