相关实验视频

Updated: Jun 15, 2025

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat

Published on: June 9, 2021

纤维基原体:在肉中预防乳腺肌肉肌病的潜在目标

Usuk Jung¹, Minjeong Kim¹, Brynn H Voy¹

¹Department of Animal Science, University of Tennessee, Knoxville, TN, United States.

Frontiers in physiology

|August 28, 2024

概括

brojlers 的遗传选择导致乳腺肌肉肌病. 纤维基原体 (FAPs) 有关,这表明它们是减少这些肉质问题的新目标.

科学领域:

动物科学动物科学
肌肉生物学肌肉生物学
兽医医学兽医医学兽医医学

背景情况:

为了生产特征而进行的现代肉养殖导致乳腺肌肉肌肉病变的增加.
这些肌肉病,以肌肉退化和纤维脂肪透为特征,对肉质有负面影响.
这些病变与人体肌肉发育不良症 (如肌肉发育不良症和肉症) 有相似之处.

研究的目的:

审查涉及肉乳腺肌肉肌肉病变中的纤维基原始体 (FAP) 的证据.
探索FAP作为治疗干预的潜在新目标.
突出了在中FAPs的表征的需要.

主要方法:

审查现有的基因表达研究和有关 brojler myopathies 的文献.
检查FAP在哺乳动物肌肉发育和疾病中的已知作用.
肉肌肉病与人类肌肉病的比较分析.

主要成果:

基因表达研究表明,FAPs与肉木乳房和相关疾病有关.
FAPs是介酶干细胞,能够分化为纤维细胞和脂肪细胞.
FAPs已被确认为对小鼠和人类肌肉病的贡献者.

结论:

纤维基原体 (FAPs) 可能参与胸肌肌病变的发病.
针对FAP可能提供一种新的策略,以减轻这些疾病的发生率和进展.
进一步描述肉FAP是有必要的,以验证它们的作用和探索治疗潜力.

关键词:

brojler 肉肉是一个纤维基原始体的原始体骨髓病变是一种神经病变.胸部主要的巨乳.白色的脱落是为了剥离.木制的乳房是木制的

更多相关视频

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

Published on: May 26, 2022

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

相关概念视频

Formation of Muscle Fibers from Myoblasts

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...