信息处理速度在大脑重塑和情节性记忆之间的关系中起的调节作用,在amnestic轻度认知障碍中
Jie Ma1, Juan-Juan Lu1,2, Jia-Jia Wu1
1Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
概括
信息处理速度 (IPS) 影响情节性记忆 (EM) 和轻度认知障碍中的大脑变化. 增强IPS可能会改善aMCI患者的记忆.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 医疗成像医学成像
背景情况:
- Amnestic轻度认知障碍 (aMCI) 涉及到大脑结构和功能的改变.
- 情节性记忆 (EM) 在aMCI中经常受到损害.
- 信息处理速度 (IPS) 对这些变化的影响尚未完全理解.
研究的目的:
- 调查IPS在EM和aMCI中大脑重塑之间的关系中的调节作用.
- 探索IPS如何影响多个层面 (区域,连接,网络) 的记忆性能和神经成像指标之间的关联.
主要方法:
- 招募了48名aMCI患者和50名健康对照 (HC).
- 进行了神经心理评估和多式磁共振成像.
- 利用调节模型来分析IPS对EM和成像特征的影响.
主要成果:
- IPS显著增强了回忆和左下椎皮层厚度之间的正相关性.
- IPS扩大了识别和左下叶/右尾功能连接 (FC) 之间的负相关性.
- IPS调节了回忆/识别和左前带带皮层的节点聚类系数之间的关联.
结论:
- 在aMCI中,IPS充当了情节性记忆表现和神经成像指标之间的调节者.
- 在aMCI中,大脑功能和结构的改变被IPS调节.
- 针对IPS的治疗干预可能有助于改善MCI中的EM.
相关概念视频
Role of Cerebellum and Prefrontal Cortex in Memory
396
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
396
Working Memory
149
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
149
Higher Mental Functions of Brain: Learning and Memory
715
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
715
Cognitive Development During Adulthood
72
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
72
Role of Neurotransmitters in Memory
488
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
488
Role of Hippocampus in Memory
195
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
195


