在多发性硬化症中,认知进展独立于复发
Tom A Fuchs1,2,3, Menno M Schoonheim1, Robert Zivadinov2,3,4
1MS Center Amsterdam, Department of Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
概括
复发性复发性多发性硬化症 (RRMS) 的认知衰退可以独立于复发发生,这种现象被称为独立于复发活动 (PIRA) 的认知进展. 这项研究证实认知PIRA在RRMS患者中很常见.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 临床研究 临床研究
背景情况:
- 复发性复发性多发性硬化症 (RRMS) 的特点是复发和缓解,但也有进展.
- 独立于复发活动的进展 (PIRA) 描述了与临床复发无关的身体残疾恶化.
- 在RRMS中认知衰退的发生和特征独立于复发活动仍然需要确定.
研究的目的:
- 在RRMS患者中研究独立于复发活动 (PIRA) 的认知衰退现象.
- 通过标准化认知测试和临床数据来定义和量化认知PIRA.
- 在RRMS中探索与认知PIRA相关的因素.
主要方法:
- 对336名RRMS患者的回顾性分析.
- 使用可靠的变化指数截止值来确定认知衰退,用于符号数字模式测试,简要视觉空间记忆测试-修订和加利福尼亚州口头学习测试-II.
- 如果在评估之间或在认知衰退前9个月内没有复发,认知衰退被归类为PIRA.
主要成果:
- 超过一半的参与者 (50.3%) 在基线时有认知障碍.
- 在那些经历认知衰退的人中 (n=167),89%的人符合认知PIRA的标准.
- 大多数认知衰退事件 (68.1%) 独立于扩展残疾状况量表 (EDSS) 评分的恶化.
- 认知PIRA与评估频率增加和评估密度降低有关.
结论:
- 这项研究确定了RRMS认知PIRA的概念和患病率.
- 认知PIRA是RRMS认知衰退的重要贡献者,独立于临床复发发生.
- 了解认知PIRA增强了对RRMS逐渐认知障碍的知识.
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