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在儿科慢性病中高血压和左心室应变
Alexander J Kula1, Yunwen Xu2, Garick D Hill3
1Division of Pediatric Nephrology, Ann and Robert H. Lurie Children's Hospital of Chicago, IL (A.J.K.).
Hypertension (Dallas, Tex. : 1979)
|August 28, 2024
概括
患有慢性病的儿童的高血压与左心室全球纵向应变 (LV GLS) 的减少有关,这是心肌健康的标志物. 这一发现突显了高血压在儿科病中对心血管的影响.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 儿科 儿科 儿科
背景情况:
- 左心室全球纵向应变 (LV GLS) 是心肌功能障碍的敏感指标.
- 减少LV GLS在患有慢性病 (CKD) 和高血压的成年人中很常见,与不良心血管结果相关.
- LV GLS可能作为儿童CKD相关心肌功能障碍的生物标志物,尽管数据有限.
研究的目的:
- 在儿童慢性病 (CKiD) 研究队列中描述LV GLS.
- 调查患有CKD的儿童血压 (BP) 和降低LV GLS之间的关联.
主要方法:
- 使用单个角四腔回声心脏成像来估计LV GLS.
- 分析与临床BP和24小时门诊BP监测数据相关联,绝对LV GLS和LV GLS在16分隔.
- 在统计分析中使用了通用估计方程,并对年龄,性别,种族,eGFR和LVH等共变量进行了调整.
主要成果:
- 在962次个人访问中测量了LV GLS,其中77次评估显示LV GLS<16.
- 临床缩和腹缩血压百分位都与LV GLS <16.6相关.
- 通过 ambulatory BP 监测检测到的透缩高血压与较低的绝对 LV GLS 值有显著的联系.
结论:
- 基于办公室的静脉缩和静脉缩高血压与慢性病儿童的LV GLS降低有关.
- 只有通过门诊血压监测发现的透气性高血压显示出与较低的LV GLS有显著的关联.
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