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在心力衰竭患者与保存的喷射分数和自身免疫性疾病患者的氧化启动后住院治疗
Munaza Riaz1, Haesuk Park1, Carl J Pepine2
1Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Journal of internal medicine
|August 28, 2024
概括
氧化 (HCQ) 的使用与HFpEF和自身免疫性疾病患者心力衰竭住院治疗的减少有关. 这项研究表明,HCQ可能会减少这一高风险组的心血管事件.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知氧化 (HCQ) 可以减少自身免疫患者的心血管事件.
- 有关HCQ的心血管安全存在担忧,促使进一步调查.
- 保存喷射分数 (HFpEF) 的心力衰竭代表了相当大的心血管疾病负担.
研究的目的:
- 评估启动氧化chloroquine (HCQ) 和住院治疗心力衰竭和所有原因之间的联系.
- 评估HCQ对被诊断患有HFpEF和自身免疫疾病的患者的影响.
主要方法:
- 一项队列研究利用了MarketScan数据库 (2007-2019) 包括患有HFpEF和自身免疫性疾病的患者.
- 倾向性得分匹配用于比较HCQ用户与非用户 (1:≥3比率).
- 考克斯的比例危险回归模型分析了与HF相关的和所有原因的住院治疗.
主要成果:
- 这项研究包括2229名患者 (592名HCQ使用者,1637名非使用者) 的后倾向分数匹配.
- HCQ使用者表现出与心力衰竭相关的住院住院风险明显降低 (aHR,0.44;95% CI,0.24-0.82).
- 在HCQ使用者中观察到所有原因住院的风险降低 (aHR,0.69;95%CI,0.57-0.83).
结论:
- 开始使用氧化 (HCQ) 与患有HFpEF和自身免疫性疾病的患者中HF相关住院病例的减少有关.
- 开始HCQ也与该患者队伍内全因住院病例的减少相关.
- 研究结果表明,HCQ在特定患者群体中具有潜在的心脏保护作用.
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