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Updated: Jun 15, 2025

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氨基酸β激活的微质细胞可以诱导复合蛋白质病变

Sang Hwan Lee1,2, Eun-Jin Bae1,2, Dayana Perez-Acuna1

  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

Brain : a journal of neurology
|August 28, 2024
PubMed
概括

在小鼠中,由粉样β寡合体激活微质会触发类似阿尔茨海默氏症的病理,包括病和同核病. 这种神经炎症驱动混合蛋白质病变和认知缺陷,凸显了微质的中心作用.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.微质细胞中的微质细胞神经退行症的神经退行症神经炎症是一种神经炎症.知道的 知道的 知道的α-synuclein 是一种同核蛋白.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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