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在母体肠道微生物群和宏观体之间存在关联

Zixin Zhong^1,2, Rongjing An³, Shujuan Ma^1,4

¹Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410013, China.

|August 28, 2024

概括

怀孕早期母亲肠道细菌的组成与胎儿的宏观性有关. 特定的细菌,如Bacteroides物种和功能通路,在具有宏观婴儿的母亲中更为丰富,这表明其具有预测作用.

科学领域:

微生物组研究微生物组研究
孕产妇和胎儿医学孕产妇和胎儿医学
基因组学和生物信息学

背景情况:

胎儿巨 (出生体重≥4000g) 对母亲和婴儿构成风险.
母亲肠道微生物组影响胎儿肠道微生物组的发展.
母亲肠道微生物群和胎儿宏观体之间的特定关系尚未得到充分理解.

研究的目的:

为了识别与胎儿宏观症相关的肠道微生物群.
探索将母体肠道微生物群与宏观菌群联系起来的潜在机制.
使用母体肠道微生物群开发一个早期怀孕预测模型,用于宏观症.

主要方法:

嵌套病例对照研究涉及93名孕妇 (31名患有巨,62名对照).
便样本的甲基因组学分析,以比较肠道微生物组的组成和功能.
相关性分析和随机森林建模用于关联和预测.

主要成果:

在宏观婴儿的母亲中增加了Bacteroides salyersiae,Bacteroides plebeius,Ruminococcus lactaris和Bacteroides ovatus的丰富性.
功能途径升高,包括宏观体组中的 gondoate 生物合成和 cis-vaccenate 生物合成.
结合四种差异物种和四个临床指标的预测模型实现了高精度 (AUC 0.935培训,0.909验证).

结论:

在怀孕早期,母亲的肠道微生物群与胎儿的宏观体发育有显著的关联.
特定的肠道细菌及其代谢途径可能有助于宏观菌的病变发生.
早期的母体肠道微生物群概况显示,作为预测和潜在地预防胎儿宏观症的非侵入性工具具有前途.

关键词:

生物标志物生物标志物我们的肠道微生物组.麦克罗索米亚 (Macrosomia) 是一个宏观的现象.甲基因组学分析的方法怀孕怀孕怀孕怀孕怀孕怀孕

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