与HBV相关的急性至慢性肝衰竭患者的侵入性肺性阿斯伯吉洛症
Man Yuan1,2, Ning Han1,2, Duoduo Lv1,2
1Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Journal of fungi (Basel, Switzerland)
|August 28, 2024
概括
侵袭性肺阿斯伯吉洛症 (IPA) 在与HBV相关的慢性肝衰竭 (HBV-ACLF) 的患者中显著增加90天的死亡率,主要是由于呼吸系统衰竭. 白细胞计数可能有助于监测IPA的发展和患者的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 与乙型肝炎病毒 (HBV) 相关的慢性肝衰竭 (ACLF) 急性肝炎是一种严重的疾病.
- 侵入性肺阿斯伯吉洛症 (IPA) 是一种严重的机会性感染,可以影响重症患者.
研究的目的:
- 在HBV-ACLF患者中研究IPA的临床特征.
- 为了确定与IPA发展和这一群体的死亡率相关的因素.
- 评估在HBV-ACLF中对IPA的抗真菌治疗和治疗药物监测.
主要方法:
- 一项病例对照研究,将44名可能患有IPA的患者与88名没有肺部感染的患者进行比较.
- 分析临床数据,包括白细胞计数和呼吸衰竭.
- 对伏利康纳治疗和血药物度监测的评估.
主要成果:
- 与对照组 (15.9%) 相比,HBV-ACLF和IPA患者的90天死亡率 (38.6%) 显着更高.
- 升高的白细胞计数是IPA发展的一个独立因素 (OR 1.468).
- 呼吸衰竭与IPA (OR 26) 的HBV-ACLF患者的死亡率密切相关.
- 进行了沃里康纳治疗,治疗药物监测显示,在某些情况下,超治疗度.
结论:
- 白血细胞计数可以作为监测HBV-ACLF患者IPA的标志物.
- IPA的存在加剧了HBV-ACLF的死亡率,主要是由呼吸衰竭引起的.
- 优化伏利康纳治疗方案和密切监测血液水平对于这些危急患者的IPA管理至关重要.
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