动态共价玻酸功能化酸/PVA水凝用于pH值和切割响应药物递送
Yessenia Oyarzún1, José Ulloa1, Matías Ceballos1
1Departamento de Polímeros, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4070386, Chile.
Gels (Basel, Switzerland)
|August 28, 2024
概括
这项研究开发了使用酸功能化的酸盐和聚乙醇 (PVA) 进行控制的甲基胺化物释放的响应pH的水凝. 这些动态共价凝提供对pH值和机械力敏感的调节性药物递送.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 基于酸盐的水凝对药物输送有希望.
- 控制水凝的特性,如粘度和刚度,对于药物释放至关重要.
- 动态共价化学提供可调和响应的材料特性.
研究的目的:
- 为了研究由酸功能化酸盐和聚乙烯醇 (PVA) 制成的水凝,用于控制的甲基胺化物释放.
- 了解PVA分子重量,pH和剪压对水凝特性和药物释放的影响.
- 探索这些水凝在触发药物释放应用中的潜力.
主要方法:
- 合成酸功能化的酸盐与不同分子重量的PVA混合.
- 在不同的pH值和剪切条件下,水凝的粘弹性 (粘度,刚度) 特性.
- 作为pH值和剪切应力函数的metoclopramide化释放特征的体外评估.
主要成果:
- 由于网络连接的增强,水凝的粘度和刚度随着更高的PVA分子量和性pH值而增加.
- 酸性pH条件促进了metoclopramide化的释放,原因是酸盐结的不稳定性.
- 在测试的剪切速度下,剪切力影响了矩阵刚性和药物释放动力学.
- 开发的AlgBA/PVA水凝证明了对pH反应和机械敏感的药物释放.
结论:
- 酸功能化的酸盐/PVA水凝具有可调节的特性和pH响应的药物释放.
- 这些水凝中的动态共价键允许对外部机械力的敏感性.
- 这些水凝显示出由生理条件触发的智能药物输送系统的潜力.
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