眼腺是否可能被SARS-CoV-2感染?
Jinghua Bu1, Minjie Zhang1, Rongrong Zhang1
1Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China.
Diseases (Basel, Switzerland)
|August 28, 2024
概括
该研究发现, ангиотензин转化酶2 (ACE2) 存在于眼腺,包括梅博姆腺. 在眼睛中,S蛋白与ACE2结合会导致炎症和细胞死亡.
科学领域:
- 眼睛表面科学 眼睛表面科学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- ангиотензин转化酶2 (ACE2) 是SARS-CoV-2病毒的一个关键受体.
- 了解眼睛组织中的ACE2表达对于评估眼睛参与病毒感染至关重要.
研究的目的:
- 为了确定各种眼腺中的ACE2表达水平.
- 研究病毒S蛋白对表达ACE2.2的眼组织的影响.
主要方法:
- 用于实验模型的男性C57BL/6J小鼠.
- 进行共免疫沉试验以确认蛋白质结合.
- 分析了CD45+细胞透和与炎症相关的细胞因子表达.
主要成果:
- 梅博姆腺体的ACE2表达最高,其次是结膜,角膜和眼腺体.
- 证实了S蛋白与ACE2的直接结合在眼睛表面表皮和梅博姆腺体中.
- S蛋白治疗导致CD45+细胞透,细胞因子上调和显著的细胞亡.
结论:
- 梅博姆腺,角膜和结膜表达ACE2.
- 病毒S蛋白可以诱导眼睛表面上皮质和梅博姆腺细胞的炎症和亡.
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