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探索暴露体谱:揭示非传染性慢性疾病中的内源和外源因素
Laura Di Renzo1, Paola Gualtieri1, Giulia Frank2,3
1Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Diseases (Basel, Switzerland)
|August 28, 2024
概括
暴露组,包括所有生命暴露,与慢性疾病有关. 了解这些环境和生物因素是预防和治疗非传染性疾病 (NCD) 的关键.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 暴露组包括所有生命暴露:生物,化学,物理,心理,关系和社会经济.
- 暴露的持续时间,强度和相互作用对于理解健康结果至关重要.
- 空气污染和社会经济地位等因素有助于代谢,心血管,神经退行性疾病,不孕症和癌症.
研究的目的:
- 研究暴露体在非传染性疾病 (NCD) 的预防,发展和进展中的作用.
- 专注于导致非传染性疾病的内源性和外源性因素的相互作用.
- 突出需要先进的分析方法和复杂的工具来进行暴露组分析.
主要方法:
- 综合毒理学和其他科学学科的跨学科方法.
- 环境和生物刺激的分析,包括饮食模式和肠道微生物群.
- 使用先进的分析方法测量各种矩阵 (生物流体,食品,空气,水,土壤) 中的污染物.
主要成果:
- 长期暴露于刺激会导致持续的低度炎症,这是NCDs的关键因素.
- 非传染性疾病受生活方式选择 (吸烟,饮食,不活动,酒精) 的影响,这些选择是由遗传,环境和社会因素所塑造的.
- 超加工食品可以加剧炎症并改变肠道微生物群.
结论:
- 暴露组显著影响非传染性疾病的发展和进展.
- 将暴露组分析集成到精准医学中可以改善疾病的诊断和治疗.
- 了解累积化学风险和多因素影响对于公共卫生战略至关重要.
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