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Updated: Jun 15, 2025

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激活VGLL4可以抑制心肌细胞成熟的高性生长

Aaron Farley1, Yunan Gao1,2, Yan Sun1

  • 1Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501, USA.

Cells
|August 28, 2024
PubMed
概括

静脉状4 (VGLL4) 通过抑制YAP/TAZ-TEAD通路和PI3K-AKT信号传递来抑制心肌细胞成熟性缩. 这一发现显示了VGLL4的存在.

关键词:
河马-YAP通道的路径.我们的 TEAD TEAD 团队.VGLL4 VGLL4 在线视频哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈这是心肌细胞 (cardiomyocyte).成熟过度缩的成长过度缩

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
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