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来自棕藻的fucoidans的体外抗HIV-1活性

Marina N Nosik1, Natalya V Krylova2, Roza V Usoltseva3

  • 1I.I. Mechnikov Institute of Vaccines and Sera, 105064 Moscow, Russia.

Marine drugs
|August 28, 2024
PubMed
概括

海洋鱼在抑制人类免疫缺陷病毒 (HIV) 复制方面表现有前途. 一项研究发现,这些化合物有效抑制HIV-1,特别是通过阻断病毒细胞相互作用的早期阶段.

关键词:
艾滋病病毒-1 艾滋病病毒-1抗艾滋病毒-1 活性.棕色藻类是一种色藻类.这是一场富科丹斯舞蹈.

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...