分支链氨基酸,氨酸和甲状腺功能:基于核磁共振 (NMR) 的横截面方法来自ELSA-巴西
Carolina Castro Porto Silva Janovsky1,2, Vandrize Meneghini1, William Tebar1
1Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil.
Metabolites
|August 28, 2024
概括
甲状腺功能会影响氨基酸水平,特别是分支链氨基酸 (BCAA) 和氨酸. 亚临床甲状腺功能低下症与异黄素和氨酸有积极的关联.
科学领域:
- 内分泌学和新陈代谢学
- 生物化学 生物化学
背景情况:
- 甲状腺激素与氨基酸代谢,特别是分支链氨基酸 (BCAA) 和氨酸之间的相互作用尚未得到充分理解.
- 甲状腺激素在调节代谢过程中起着至关重要的作用,影响蛋白质的合成和降解.
研究的目的:
- 在一般人群中调查甲状腺功能参数与BCAA (氨酸,异氨酸,氨酸) 和氨酸水平之间的关联.
- 探索这些协会在euthyroid个体,和那些亚临床甲状腺功能障碍和甲状腺功能障碍.
主要方法:
- 利用了ELSA-巴西队列研究中的4098名参与者的数据.
- 评估甲状腺刺激激素 (TSH),自由T4 (FT4) 和自由T3 (FT3) 水平,以及FT4:FT3比率.
- 使用自动化NMR平台量化氨基酸水平,并使用皮尔森系数和线性回归模型分析相关性.
主要成果:
- 较高的TSH水平与增加的阿拉宁相关.
- FT4水平与异黄素相反相关,而FT3水平与氨酸和氨酸正相关.
- 亚临床甲状腺功能低下症与更高的异黄素和氨酸水平一致相关.
结论:
- 甲状腺功能,包括TSH,FT4,FT3和它们的比率,与BCAA和氨酸水平有关.
- 亚临床甲状腺功能低下症显示与异黄素和氨酸有显著的积极关联.
- 需要进一步的研究来阐明关联甲状腺状况和氨基酸代谢的潜在机制.
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