在患有后COVID-19感染的参与者中长期的神经认知和神经精神病学后续:一项纵向研究
Marta Almeria1, Juan Carlos Cejudo2, Joan Deus3,4
1Department of Neurology, MútuaTerrassa University Hospital, 08221 Barcelona, Spain.
Neurology international
|August 28, 2024
概括
认知功能,包括记忆和执行功能,在COVID-19感染后的六个月内得到改善. 然而,无论疾病的严重程度如何,疲劳和焦虑等持续症状是常见的.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 在COVID-19之后报告了认知障碍和持续症状.
- 了解认知变化的轨迹及其与临床因素的关联至关重要.
研究的目的:
- 在6个月的随访期评估COVID-19幸存者的认知变化.
- 探索认知变化,临床症状,情绪困扰和疾病严重程度之间的关联.
主要方法:
- 一项200名参与者 (20-60岁) 的纵向队列研究,确认了COVID-19.
- 神经心理测试评估注意力,记忆力,语言和执行功能10-30天和出院6个月后.
- 排除标准包括先前存在的认知,神经或精神疾病.
主要成果:
- 6个月后观察到的语言/视觉记忆,处理速度,执行功能和命名 (p < 0.001) 的显著改善.
- 认知改善独立于最初的疾病严重程度和主观认知投诉.
- 在具有主观认知投诉的参与者中,观察到焦虑和抑郁的比率更高 (p < 0.01).
结论:
- 在COVID-19后持续的症状很常见,经常包括认知问题,疲劳和情绪障碍.
- 在6个月后,COVID-19严重程度和认知障碍之间没有发现直接关联.
- 经过6个月,无论疾病的严重程度或最初的投诉,神经心理和精神病理上的改善都发生了.
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