杀虫剂和除草剂对斑马鱼甲状腺疾病的影响
Tingting Ma1,2,3, Xiangji An1, Peng Wu4
1College of Resource Environment & Tourism, Hubei University of Arts & Science, Xiangyang 441053, China.
Toxics
|August 28, 2024
概括
杀虫剂,特别是杀虫剂,比除草剂更能破坏斑马鱼的甲状腺功能. 特定的杀虫剂,如penpropathrin和atrazine是关键的甲状腺干扰剂,影响人类健康风险评估.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 对毒理学的比较.
背景情况:
- 甲状腺癌是全球最常见的癌症,通常与甲状腺功能障碍有关.
- 环境污染物,特别是变异性农药,与甲状腺功能障碍有关.
- 斑马鱼 (Danio rerio) 由于与人类的生理和毒理相似之处,可以作为一个有价值的模型.
研究的目的:
- 为了比较杀虫剂和除草剂对斑马鱼甲状腺功能的直接和间接毒性.
- 为了识别作为甲状腺破坏剂的特定农药.
- 评估甲状腺干扰以外的更广泛的毒理影响.
主要方法:
- 对斑马鱼中各种杀虫剂和除草剂的毒性数据的比较分析.
- 评估有效度以确定整体毒性.
- 对甲状腺激素水平,HPT轴基因表达和其他毒理终点的影响的调查.
主要成果:
- 杀虫剂对斑马鱼甲状腺的整体毒性比除草剂更大.
- 普拉林和阿特拉被确定为显著的甲状腺干扰剂.
- 基拉尔杀虫剂对父母和后代斑马鱼表现出复杂的毒性影响.
- 观察到的影响包括甲状腺激素水平的改变,基因表达,发育性毒性,免疫毒性和氧化损伤.
结论:
- 杀虫剂对甲状腺功能构成重大风险,杀虫剂是更强大的破坏者.
- 斑马鱼模型对于识别破坏甲状腺的农药是有效的.
- 这些发现对于人类健康风险评估和对地表水污染物的生态监测至关重要.
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