针对儿童神经性膀功能障碍的肠道肉丁毒素-A注射:过去10年的研究总结更新
Andrea Zulli1, Virginia Carletti1,2, Alberto Mantovani1
1Department of Pediatric Urology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.
Toxins
|August 28, 2024
概括
静脉内注射的肉毒素-A (BTX-A) 注射是有效和安全的治疗神经性膀 (NB) 在儿童. 这次审查证实BTX-A是儿科神经性膀管理的有价值策略.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经性膀 (NB) 在儿科泌尿病学中提出了重大挑战.
- 内毒素A (BTX-A) 注射是NB的治疗选择,通常在保守措施失败后和侵入性手术之前使用.
- 关于最佳儿科NB治疗的共识仍然难以达成.
研究的目的:
- 在过去十年中,审查和综合了对BTX-A小儿神经性膀的膀注射的研究.
- 评估BTX-A治疗在NB儿童中的疗效,安全性和结果.
- 识别当前治疗方案中的趋势和不一致性.
主要方法:
- 对过去10年PubMed索引的研究进行了系统审查.
- 两位作者根据预先定义的纳入标准独立选择了文章.
- 提取的数据包括患者人口统计,神经疾病,BTX-A治疗细节,临床/泌尿动力学参数,不良事件和结果.
主要成果:
- 该审查分析了16项研究,包括630名患有NB的儿科患者,平均年龄为9.7岁.
- 骨髓炎是最常见的神经学诊断 (40%).
- BTX-A注射在治疗儿科NB的治疗中显示出整体疗效和安全性.
结论:
- 肠道BTX-A是一种有价值和安全的治疗策略,用于治疗儿科患者的神经性膀.
- 尽管有效性已被证明,但在已发表的治疗方案和研究标准化中存在显著的异质性.
- 需要进行进一步的研究,以制定在儿科中使用BTX-A的统一指导方针.
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