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相关概念视频

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

477
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
477
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

661
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
661

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Standing Neurophysiological Assessment of Lower Extremity Muscles Post-Stroke
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毒素A型 (BoNT-A) 用于中风后性:使用自然语言处理和机器学习的多中心研究.

María Jesús Antón1, Montserrat Molina2, José Gabriel Pérez3

  • 1Department of Physical Medicine and Rehabilitation, Rio Hortega University Hospital, 47007 Valladolid, Spain.

Toxins
|August 28, 2024
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概括

四分之一的中风后性患者接受了A型肉毒素 (BoNT-A) 缓解疼痛,通常是在中风后的一年. 改善数据和早期治疗是改善患者护理的关键.

关键词:
人工智能的人工智能是人工智能.肉毒毒素A是一种肉毒毒素.电子健康记录是电子健康记录.缺血性中风 中风机器学习是机器学习.自然语言处理自然语言处理.在中风后的性.

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科学领域:

  • 神经学 神经学
  • 康复医学 康复医学 康复医学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 脑卒中后性 (PSS) 是一种常见的并发症,影响患者的康复和生活质量.
  • 有效管理PSS往往需要采用多模式的方法,包括药理和非药理干预措施.
  • 毒素A型 (BoNT-A) 是一种被公认的焦点的治疗方法,但其在PSS中的实际利用模式需要进一步描述.

研究的目的:

  • 描述用于治疗中风后性 (PSS) 的甲型肉毒素 (BoNT-A) 的利用模式.
  • 在现实环境中分析患者人口统计,中风特征和治疗方法.
  • 确定影响BoNT-A使用的因素以及PSS管理的改进领域.

主要方法:

  • 这是一项多中心的回顾性研究,使用了五家西班牙医院的电子健康记录 (EHR).
  • 自然语言处理 (NLP) 和机器学习 (EHRead®技术) 结合SNOMED CT术语被用于数据提取.
  • 分析包括患者人口统计,中风细节,BoNT-A治疗时间和适应症,以及2190名PSS患者的同时治疗.

主要成果:

  • 在2190名PSS患者中 (平均年龄为69岁,52.1%为男性),25.5%接受了BoNT-A. 性开始的中位时间为205天,第一次BoNT-A注射的中位时间是中风后的364天.
  • 对于BoNT-A的首要指示是疼痛控制. 康复是最常见的非药物治疗 (95.5%).
  • 只有3.3%的患者在他们的电子健康记录中记录了性监测尺度.

结论:

  • 在四分之一的PSS患者中使用BoNT-A,主要用于疼痛管理,通常在中风后大约一年.
  • 目前的数据突出显示BoNT-A治疗启动的显著延迟和标准化监测尺度的有限使用.
  • 提高早期治疗策略,系统性疾病监测和改善电子健康记录中的数据文档对于优化PSS患者护理至关重要.