对慢性肝胆道疾病的狗的肠道微生物群和便胆酸的协生药物管理的影响:一项随机病例对照研究
Verena Habermaass1, Corrado Biolatti2, Francesco Bartoli3
1Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, Italy.
Veterinary sciences
|August 28, 2024
概括
在患有慢性肝病的狗中,同生菌治疗减少了肝酶和胃肠道症状. 肠道微生物组分析显示,细菌群体发生了变化,这表明共生菌是治疗犬肝病的潜在治疗标.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肠道微生物组的改变与人类慢性肝病有关.
- 在患有慢性肝病的狗中观察到肠道失调.
- 有限的临床试验存在于犬肝病中的共生疗效.
研究的目的:
- 为了评估同生菌复合物在患有慢性肝胆病的狗中给予的疗效.
- 评估协生菌对临床症状,肝酶和肠道微生物组合的影响.
主要方法:
- 32只患有慢性肝胆道疾病的狗被随机分配到一个共生治疗组 (TG) 和一个控制组 (CG).
- 干预持续了4-6周,评估包括临床评估,血液检查,超声波,便胆酸和肠道微生物组分析.
- 统计分析比较了TG和CG之间的结果.
主要成果:
- 与对照组相比,同生菌治疗显著降低了阿氨酸转移酶 (ALT) 活性 (p = 0.007) 并消除了胃肠道症状 (p = 0.026).
- 与对照组相比,共生组的Enterobacteriaceae和Lachnospiraceae的增加较低.
- 没有观察到总体微生物丰富度,物种数量或便胆酸概况的显著变化.
结论:
- 协生菌的使用在慢性肝病的狗中有望改善临床和生化参数.
- 需要进一步的研究来阐明特定的代谢途径,并优化对狗肝脏疾病的协生疗法.
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