相关实验视频

Updated: Jun 15, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

人类心力衰竭的肌肉心脏超结构与保存的喷射分数

Mariam Meddeb¹, Navid Koleini¹, Aleksandra Binek²

¹Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Nature cardiovascular research

|August 28, 2024

概括

肥胖会使心力衰竭与保存的喷射分数 (HFpEF) 恶化. 严重的肥胖会损害心脏肌肉结构,损害能量生产和脂肪处理,无论糖尿病状况如何.

科学领域:

心脏病学心脏病学
病理学病理学病理学
代谢疾病代谢疾病

背景情况:

保存喷射分数 (HFpEF) 的心力衰竭影响了超过一半的心力衰竭患者,其特点是患病率和死亡率高.
肥胖是HFpEF的主要并发症,显著恶化疾病进展和患者预后.
之前的研究表明,患有致病性肥胖的HFpEF患者心肌异常,包括刺激的张力受损和线粒体和脂质代谢基因表达失调.

研究的目的:

研究严重肥胖对HFpEF患者心肌超结构的影响.
为了将观察到的超结构变化与心肌蛋白质组学数据相关联.

主要方法:

从患有HFpEF的患者获得了部心肌活检.
使用传输电子显微镜来评估心肌超结构.
心肌蛋白质学是为了分析与代谢途径相关的蛋白质表达而进行的.

主要成果:

在HFpEF患者中观察到显著的瘤破坏和瘤溶解.
线粒体异常,包括胀和晶状体溶解,以及脂肪滴积累增加是突出的,特别是在严重肥胖的患者中.
这些变化与并发性糖尿病无关.
蛋白质组分析显示,参与脂肪酸吸收,加工,氧化和线粒体呼吸的蛋白质的表达减少,特别是在最肥胖的HFpEF患者中.

结论:

严重的肥胖会导致HFpEF显著的心肌超结构损伤,包括瘤和线粒体病理.
在HFpEF中,与肥胖有关的心肌功能障碍与脂肪酸代谢和线粒体功能受损有关.
这些发现凸显了肥胖在HFpEF病理生理学中的有害作用,并表明了潜在的治疗点.

更多相关视频

Ultrasonic Assessment of Myocardial Microstructure

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

相关概念视频

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...

Layers of the Heart Wall

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...