心脏代谢风险因素的年龄取决于性别差异
Daria V Zhernakova1,2, Trishla Sinha3, Sergio Andreu-Sánchez3,4
1Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. dashazhernakova@gmail.com.
心脏代谢风险因素的性别差异很常见,并且经常随着年龄的增长而变化. 了解这些与年龄相关的变化对于研究男性和女性心脏代谢疾病 (CMD) 至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 心脏代谢性疾病 (CMD) 构成了全球严重的健康负担.
- 在CMD预后,发病和临床表现方面存在显著的性别差异.
研究的目的:
- 为了研究心脏代谢风险因素的年龄取决于性别差异.
- 检查生活方式因素对这些性别和年龄相关变化的影响.
主要方法:
- 分析了45种表型和6种生活方式因素.
- 利用了荷兰生命线队列中的146,021名参与者的数据.
- 对心脏代谢表型的性别和年龄相互作用的统计检查.
主要成果:
- 在71%的评估表型中观察到性别差异.
- 在这些表型的31%中,确定了年龄相关的性别差异.
- 脂质水平表现出强烈的年龄改变的性别差异,而体重指数 (BMI) 显示没有显著的性别差异.
结论:
- 心脏代谢风险因素的性别差异很普遍,并且受到年龄的显著影响.
- 生活方式因素以性别和年龄特定的方式调节心脏代谢表型.
- 纳入年龄作为一个变量对于准确研究CMD的性别差异至关重要.
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