短暂禁欲与丸精子对精子DNA碎片化的影响:系统性审查和元分析
Nir Kugelman1,2, Alyssa Hochberg3,4, Michael H Dahan3
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada. nirkug@gmail.com.
Archives of gynecology and obstetrics
|August 28, 2024
概括
丸精子 (TS) 显示精子DNA碎片化 (SDF) 低于短暂禁欲后射精的精子. 这一元分析表明,TS可能会改善不孕症中的SDF,但需要进行直接比较.
科学领域:
- 生殖医学 生殖医学
- 精子生物学 精子生物学
- 遗传学 是一个遗传学.
背景情况:
- 精子DNA完整性对于成功受精和胚胎发育至关重要.
- 提高精子DNA碎片化 (SDF) 与不孕症有关.
- 通过手术精子检索 (TESA/TESE) 检索的丸精子 (TS) 在标准禁欲期后通常比射精精的精子呈现较低的SDF.
研究的目的:
- 为了比较短暂禁欲期 (<48小时) 后获得的丸精子 (TS) 和射精精子之间的精子DNA碎片化 (SDF) 水平.
- 评估更短的禁欲期的潜力,作为减少SDF的手术精子采集的不那么侵入性的替代方案.
主要方法:
- 对16项研究进行了元分析 (4项关于TS,12项关于短暂禁欲射精).
- 搜索的数据库包括Cochrane图书馆,科学网络,Embase,MEDLINE,以及PUMBED,截至2023年11月16日.
- 使用RevMan进行统计分析,并进行调整以比较不相似的研究设计和参与者数量.
主要成果:
- 总共有641名患者被纳入 (120名TS组,521名短期戒断组).
- 与短期戒断组相比,TS组的平均SDF显著较低 (平均差异为-9.48,P < 0.001).
- 两组之间没有观察到平均年龄的显著差异.
结论:
- 丸精子 (TS) 经过短时间的禁欲后,表现出较低的精子DNA碎片化 (SDF),而不是射精的精子.
- 虽然TS在减少SDF方面可能具有优势,但需要进一步进行直接比较研究.
- 未来的研究应该调查生殖结果,以最终评估短期戒断与TS检索的有效性.
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