Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Vaccinations01:51

Vaccinations

44.2K
Overview
44.2K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

926
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
926
Cancer Vaccines01:30

Cancer Vaccines

347
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
347
Immunological Memory01:23

Immunological Memory

562
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
562
Development of Immunocompetence01:22

Development of Immunocompetence

295
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
295
Cross-reactivity00:42

Cross-reactivity

31.0K
Overview
31.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Assessment of the healthcare burden of dengue disease in Germany: a retrospective analysis of statutory health insurance data (2014-23).

Journal of travel medicine·2026
Same author

[Hantavirus infections: clinical relevance in intensive care and emergency medicine].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same author

[Osteoarthritis: epidemiology, pathophysiology, and conservative treatment options].

Innere Medizin (Heidelberg, Germany)·2026
Same author

Recombinant zoster vaccine in patients with inflammatory rheumatic diseases: efficacy, long-term protection and safety under immunosuppression.

RMD open·2026
Same author

Dermatologie (Heidelberg, Germany)·2026
Same author

Evaluation of Intravenous Administration of Anti-Infective Agents and Documentation Quality in Orthopedics and Trauma Surgery: A Quantitative Study on Discrepancies Between Physician Prescriptions and Nursing Records.

Antibiotics (Basel, Switzerland)·2026
Same journal

[Progression inhibition in chronic kidney disease].

Innere Medizin (Heidelberg, Germany)·2026
Same journal

Innere Medizin (Heidelberg, Germany)·2026
Same journal

Innere Medizin (Heidelberg, Germany)·2026
Same journal

Innere Medizin (Heidelberg, Germany)·2026
Same journal

[Optimal blood pressure control in patients with diabetes and arterial hypertension: interpreting the BPROAD study].

Innere Medizin (Heidelberg, Germany)·2026
Same journal

[Distributive justice in healthcare during times of change: a medical ethics perspective].

Innere Medizin (Heidelberg, Germany)·2026
查看所有相关文章

相关实验视频

Updated: Jun 15, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.8K

[疫苗接种] [疫苗接种] [疫苗接种]

Marco Krasselt1,2, Henning Trawinski3,4, Christoph Lübbert5,6,7

  • 1Bereich Rheumatologie, Medizinische Klinik III, Universitätsklinikum Leipzig, Leipzig, Deutschland.

Innere Medizin (Heidelberg, Germany)
|August 28, 2024
PubMed
概括
此摘要是机器生成的。

带状疹 (HZ) 的风险随着年龄和免疫抑制而增加. 重组辅助性HZ亚单位疫苗在预防50岁以上的成年人,包括免疫受损人群中,在预防HZ和PHN方面表现出高的疗效和安全性.

关键词:
这是一种疹 (Herpes zoster).免疫抑制是一种免疫抑制.神经疼痛,治疗后的治疗.疫苗,无活化的疫苗.疹-疹病毒病毒.

更多相关视频

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.2K
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
05:39

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

12.0K

相关实验视频

Last Updated: Jun 15, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.8K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.2K
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
05:39

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

12.0K

科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学
  • 传染性疾病 传染性疾病

背景情况:

  • 疹疹 (HZ),由疹疹病毒 (VZV) 再激活引起,与因衰老或免疫抑制而导致的T细胞免疫力下降有关.
  • 在年长的成人和年轻的免疫抑制剂炎症性类风湿性疾病患者中观察到增加的HZ和并发症风险 (例如,后神经痛 - PHN).
  • 某些免疫抑制疗法,包括雅努斯激酶 (JAK) 抑制剂和葡萄糖皮质类药物,会增加HZ风险.

研究的目的:

  • 评估复合辅助HZ亚单位疫苗预防HZ和PHN的疗效和安全性.
  • 评估不同年龄组和免疫受损人群的疫苗性能.
  • 为增加HZ风险的个人提供疫苗接种建议.

主要方法:

  • 对复合辅助HZ亚单位疫苗的临床试验数据的审查.
  • 分析疫苗的疗效,免疫性和安全性.
  • 考虑德国疫苗常务委员会 (STIKO) 的建议.

主要成果:

  • 该疫苗在50岁及以上的健康成年人中,在预防HZ方面表现出90-97%的疗效.
  • 在免疫功能低下和免疫抑制患者中证实了高疗效,免疫性和安全性.
  • 在临床试验中,与安慰剂相比,在疫苗组中观察到更高的反应性.

结论:

  • 重组辅助性HZ亚单位疫苗在50岁及以上的个体中对预防HZ和PHN具有高度有效性和安全性.
  • 该疫苗由STIKO推给60岁以上和50岁以上的个体,具有增加的HZ风险.
  • 根据已证明的有效性和安全性,将疫苗接种建议扩展到所有患有HZ风险增加的成年人是有必要的.