使用化物载荷奇托桑纳米粒子修饰玻璃离子体水泥预防二次
Hanife Altınışık1, Hülya Erten Can2, Necibe Başaran Mutlu Ağardan3
1Department of Restorative Dentistry, Faculty of Dentistry, Gazi University, Ankara, Emek, 06510, Turkey. hanifekamak@gazi.edu.tr.
Clinical oral investigations
|August 28, 2024
概括
在玻璃离子体水泥 (GIC) 中结合的含的奇托桑纳米颗粒显著降低了二次根. 这种修改后的GIC显示了增强的矿物质含量,对儿科牙科有很大的前景.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 纳米技术纳米技术
背景情况:
- 二次性仍然是恢复性牙科的一个重大挑战.
- 玻璃离子体水泥 (GIC) 是一种常见的修复性材料,但其抗癌性质可以得到增强.
- 基托桑及其纳米粒子为改善生物材料性能提供了潜在的潜力.
研究的目的:
- 评估将素和化物载的素纳米颗粒纳入GIC的有效性,以预防二次.
- 为了比较修改的GIC配方与传统GIC的抗原作用.
主要方法:
- 标准化腔被准备在牙中,并用传统的GIC,基多修改的GIC,或化物加载的基多纳米粒子修改的GIC恢复.
- 恢复的牙经历了热循环和多物种化生物膜挑战.
- 微计算机断层扫描 (micro-CT) 和扫描电子显微镜与能量分散式X射线光谱 (SEM/EDX) 用于分析.
主要成果:
- 与常规GIC和基托桑修改GIC相比,化物加载的基托桑纳米颗粒修改GIC显著降低了外部损伤深度.
- SEM/EDX揭示了,和的含量明显更高的牙邻加载的奇托桑纳米颗粒修改的GIC修复.
- 基托桑和化物加载的基托桑纳米粒子修饰都显示出显著的作用,减少了损伤深度 (p < 0.05).
结论:
- 将10%的酸盐和10%的化物载的酸盐纳米颗粒纳入GIC有效地防止了二次根的发展.
- 含有的奇托桑纳米颗粒在预防二次虫病方面表现出卓越的有效性.
- 经过修改的GIC,特别是含有化物载荷的奇托桑纳米颗粒,由于控制的化物释放,对儿科和预防性牙科有很大的希望.
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