在英国接受慢性口服皮质类固醇的患者中模拟不良事件
Danny Gibson1, Neil Branscombe2, Neil Martin2,3
1AstraZeneca, Health Economics, Cambridge, UK. danny.gibson@astrazeneca.com.
PharmacoEconomics - open
|August 28, 2024
概括
减少口服皮质类固醇 (OCS) 的使用与OCS节省策略提供显著的长期健康经济效益和改善质量调整寿命年 (QALYs). 这种新的建模方法捕捉了这些优势,为未来的治疗决策提供了信息.
科学领域:
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
- 临床建模 临床建模
背景情况:
- 口服皮质类固醇 (OCS) 是有效的抗炎药物,但与显著的不良事件 (AE) 和医疗保健成本有关.
- 生物制剂提供了节省OCS的替代品,但目前的模型可能低估了它们的经济价值,因为它们没有完全捕捉到OCS减少的好处.
- 提出了一种新的建模方法,以准确评估OCS节约方案的健康经济优势.
研究的目的:
- 开发和介绍一种疾病不可知模型,以量化OCS节约治疗的健康经济效益.
- 为了捕捉与减少OCS使用相关的长期成本节约和质量调整寿命年 (QALYs).
- 为新的OCS节约疗法提供决策信息.
主要方法:
- 英国卫生技术评估 (HTA) 观点被采用,用于具有终身视野和4周周期的疾病不可知模型.
- 包括与OCS相关的关键不良事件 (2型糖尿病,心血管疾病,骨质疏松症).
- 经质量调整的寿命年 (QALYs),寿命年和成本计算为OCS-only与50%的OCS-sparing治疗手臂,每日剂量不同 (5,10,15毫克).
主要成果:
- 50%的OCS剂量节省方案导致每位患者的显著终身增量成本节省,根据OCS剂量从1107英到19501英不等.
- 患者在QALY中获得了从0.033到0.356的收益,这也取决于剂量.
- 节省OCS对健康的经济效益是显著的和长期的,在35-40年后稳定.
结论:
- 开发的建模方法有效地捕捉了OCS节约的长期健康经济益处,这些益处通常被传统方法遗漏.
- 这些发现为比较新兴OCS节约疗法的成本效益提供了宝贵的见解.
- 该研究强调了旨在减少口服皮质类固醇依赖的战略的显著经济优势.
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