与APOE4相关的皮质厚度差异在中年时因性别而调节
Kaitlynne N Leclaire1, Jenna K Blujus1, Laura E Korthauer2
1Department of Psychology, University of Wisconsin-Milwaukee, 2441 E. Hartford Ave, Milwaukee, WI, 53211, USA.
Brain imaging and behavior
|August 28, 2024
概括
性和APOE4影响中年人的大脑结构. 女性表现出更厚的皮层,在阿尔茨海默病症状出现之前,女性的APOE4效应更明显.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 神经成像是一种神经成像.
背景情况:
- 阿波利波蛋白E (APOE) ε4是晚发性阿尔茨海默病 (AD) 的主要遗传风险因素,女性的风险更大.
- 现有的关于性别-APOE相互作用的研究主要集中在老年人身上,忽视了关键的中年期.
- 了解健康的中年成年人大脑结构对于识别早期AD相关变化至关重要.
研究的目的:
- 为了研究性别,APOE ε4状态和皮质厚度之间的关系,在健康的,认知不受损的中年成年人中.
- 在临床阿尔茨海默病症状出现之前,确定大脑结构的性别特异性和APOE ε4特异性差异.
主要方法:
- 结构磁共振成像 (MRI) 用于评估128名中年成人 (40-60岁) 的皮质厚度.
- 参与者被基因定型为APOE状态 (APOE4+或APOE4-).
- 统计分析对性别和APOE ε4组的皮质厚度进行了比较.
主要成果:
- 与男性相比,女性在几个区域表现出更厚的皮层,包括上额叶皮层 (双边),左侧中皮层和左侧三角皮层.
- 与APOE4个体相比,APOE4+个体的左侧面角中额头环较薄.
- 性别-APOE相互作用揭示了不同的模式:与男性相比,女性APOE4-个体在特定区域具有更厚的皮质,而女性APOE4+个体表现出更厚的双侧上额叶皮质,但与女性APOE4-个体相比,左额叶前带状皮质更薄.
结论:
- 与APOE相关的皮质厚度差异可以在中年时检测到,在明显的AD症状之前,在女性中更为明显.
- 这些发现强调了在早期大脑衰老和AD研究中考虑性别和遗传风险因素的重要性.
- 在健康的中年成年人中描述这些差异为了解AD的神经退行提供了关键的基线.
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