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Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines

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Published on: October 8, 2015

体重指数和BRAFV600E突变之间的关联可能因原发性瘤大小而异

Hyunju Park¹, Jung Heo², Hyun Jin Ryu³

¹Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

European thyroid journal

|August 28, 2024

概括

较高的体重指数 (BMI) 与甲状腺癌患者的BRAFV600E突变有关,这些患者的瘤较大 (>1厘米). 在小瘤 (≤1厘米) 的患者中没有观察到这种关联,这表明瘤大小影响了BMI-突变联系.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
流行病学流行病学

背景情况:

高体重指数 (BMI) 是甲状腺癌的已知危险因素.
在甲状腺癌中,BMI与特定的基因突变 (如BRAFV600E) 之间的关系仍在调查中.

研究的目的:

为了研究高BMI和BRAFV600E突变在乳头甲状腺癌 (PTC) 患者中存在的关联.
为了确定瘤大小是否会改变BMI和BRAFV600E突变状态之间的关系.

主要方法:

对6438名接受了BRAFV600E突变测试的PTC患者进行了回顾性分析.
后勤回归和受限制的立方斜线图被用来建模BMI和BRAFV600E突变之间的关联.
患者根据原发性瘤大小 (≤1厘米与>1厘米) 进行了分层.

主要成果:

在原发性瘤大于1厘米的患者中,BRAFV600E突变与更高的BMI显著相关 (OR: 1.034; P = 0.029).
在初级瘤≤1厘米的患者中,BMI和BRAFV600E突变之间没有显著的关联 (OR: 1.007;P = 0.570).
在这两组中,性别并不是影响这种关联的重要因素.

结论:

在PTC患者中,较高的BMI与BRAFV600E突变积极相关,主要瘤较大 (>1厘米).
体重指数和BRAFV600E突变状态之间的关联取决于主要瘤的大小.
这些发现突出了肥胖,瘤特征和甲状腺癌中的遗传改变之间的复杂相互作用.

关键词:

在BRAFV600E突变中.身体质量指数 (BMI) 是指身体质量指数.皮囊甲状腺癌是什么?皮囊甲状腺癌是什么主要瘤大小的主要瘤大小.

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