相关实验视频

Updated: Jun 15, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

细胞癌:一个回顾

Tracy L Rose^1,2, William Y Kim^1,2,3,4

¹Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill.

|August 28, 2024

概括

细胞癌 (RCC) 是一种常见的癌症,经常偶然发现. 像手术这样的早期治疗提供了很高的生存率,而新疗法则改善了晚期RCC的结果.

科学领域:

癌症学
尿道病学

背景情况:

细胞癌 (RCC) 是一个重要的全球健康问题,在美国男性中排名第六,在美国女性中排名第九.
主要亚型的清细胞RCC涉及希佩尔·林多 (VHL) 基因.
许多RCC病例 (37% - 61%) 是通过成像检测的,其中70%是早期I阶段诊断的.

研究的目的:

审查细胞癌的发病率,诊断和治疗情况.
突出管理早期和转移性RCC的进展.

主要方法:

对RCC发病率和死亡率的流行病学数据的审查.
对局部和晚期RCC的当前治疗方法的分析.
与各种治疗方法相关的生存结果的综合.

主要成果:

癌症发病率正在上升,死亡率正在下降.
在小于4厘米的瘤中进行部分瘤切除可以获得超过94%的癌症特异性5年生存率.
先进的RCC治疗,包括免疫检查点抑制剂,反应率为42%-71%.

结论:

早期的RCC通常是偶然诊断的,并通过手术或除技术有效治疗.
新兴疗法为转移性细胞癌患者提供了改善的预后.

更多相关视频

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

相关概念视频

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...