第一代抗胰岛素和幼儿发作
Ju Hee Kim1, Eun Kyo Ha2, Boeun Han3
1Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
JAMA network open
|August 28, 2024
概括
第一代抗组胺药物处方增加了22%的儿童发作风险,在6至24个月的婴儿中观察到更高的风险. 建议仔细考虑给幼儿开这些药物的处方.
科学领域:
- 儿科神经学 儿科神经学
- 药物监督 药物监督 药物监督
- 流行病学 流行病学
背景情况:
- 抗胰岛素广泛用于儿科感冒症状,但它们对中枢神经系统的影响需要意识到相关风险.
- 了解第一代抗胰岛素与儿童发作等不良事件之间的潜在联系至关重要.
研究的目的:
- 调查第一代抗组胺药物处方与儿童发作事件之间的关联.
- 量化儿童群体中与第一代抗胰岛素使用相关的发作风险.
主要方法:
- 使用韩国全国范围的医疗保险数据库,采用了自我控制的案例交叉队列研究设计.
- 包括2002年至2005年间出生的儿童,他们经历了发作事件,随访直到2019年.
- 条件后勤回归分析了在危险期和控制期期间第一代抗组胺剂暴露之间的关联.
主要成果:
- 第一代抗组胺药物处方与22.0%的发作风险增加有关 (调整后OR,1.22).
- 与25个月至6岁儿童相比,在6至24个月的儿童中 (调整后的OR,1.49) 的风险显著更高 (调整后的OR,1.11).
- 敏感性分析证实了这些发现的可靠性.
结论:
- 第一代抗组胺剂的处方与儿童发作风险增加有关,特别是在6-24个月的年龄组.
- 这些发现凸显了对初代抗组胺剂在幼儿中进行谨慎和明智的处方的需要.
- 需要进一步的研究,以充分阐明抗组胺剂使用与发作风险之间的关系.
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