多基因风险评分和精神分裂症和双极性障碍双胞胎一致性
Jie Song1,2,3, Joëlle A Pasman2,3, Viktoria Johansson3,4
1Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
JAMA psychiatry
|August 28, 2024
概括
患有精神病的多基因风险得分 (PRS) 较高的个人更有可能患有受影响的同胞. 这种对精神病的遗传责任表明了预测能力,即使在较小的样本大小.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 双胞胎研究 双胞胎研究
- 分子精神病学分子精神病学
背景情况:
- 精神分裂症和双相情感障碍具有很高的遗传性和遗传因素.
- 双胞胎和分子遗传方法可以确定这些疾病的共同遗传责任.
- 了解遗传重叠对于预测精神病风险至关重要.
研究的目的:
- 确定精神病的双胞胎一致性是否与精神病和双胞胎的多基因风险评分 (PRS) 相对应.
- 为了比较精神病病例和对照病例之间的PRS.
- 为了估计精神病的双胞胎遗传性.
主要方法:
- 一个用双胞胎数据从精神分裂症和双极双胞胎研究 (STAR) 和瑞典双胞胎注册使用的病例控制研究.
- 精神病的多基因风险评分 (PRS) 是从一项全基因组关联研究 (GWAS) 中生成的,该研究结合了精神分裂症和双相情感障碍.
- 使用结构方程建模来估计遗传性.
主要成果:
- 与对照组相比,精神病PRS在病例中明显高.
- 精神病的PRS较高与精神病的双胞胎一致性增加有关.
- 双胞胎精神病遗传率估计为0.73,在不同的队列中一致.
结论:
- 通过PRS测量精神病的遗传责任,预测了受影响的同胞双胞胎的可能性.
- PRS对于精神病具有预测价值,独立于zygosity.
- 双胞胎和分子设计的发现一致,加强了遗传因素在精神病中的作用.
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