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临床过程和 maksillary angiosarcoma 的血管内皮生长因子信号系统表达:一个病例报告

Shiho Arai¹, Takeshi Igarashi¹, Hiroki Goto¹

¹Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, Shimotsuke, Japan.

Science progress

|August 28, 2024

概括

大血管肉瘤是一种罕见的,具有攻击性的癌症. 这项案例研究发现瘤中激活了血管内皮生长因子受体 (VEGFR) 信号通路,尽管抗VEGF治疗的疗效尚不清楚.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子生物学分子生物学

背景情况:

maksillary angiosarcoma 是一种极为罕见且具有攻击性的血管内皮细胞瘤.
针对血管内皮生长因子 (VEGF) 的向疗法在癌症治疗中越来越突出.
了解罕见瘤的分子格局对于开发有效的治疗策略至关重要.

研究的目的:

报告一个患有大血管瘤的患者的临床过程.
通过免疫组织化学研究大血管肉瘤中VEGF信号分子的表达.
探索VEGFR信号传递在这种罕见恶性瘤中的潜在作用.

主要方法:

一个81岁的男性患有大血管肉瘤的临床病例呈现.
多学科治疗包括手术,放射治疗和化疗.
对VEGF信号通路组件 (VEGFR1,VEGFR2,p-Akt,MAPK,STAT3) 和肉瘤标记物 (CD31,CD34,D2-40,第八因子) 的免疫组合化学分析.

主要成果:

大血管肉瘤通过CD31阳性和其他标志物的负性证实.
尽管进行了彻底的手术切除,但患者发生了转移,并在手术后24个月死亡.
免疫组织化学检测显示对VEGFR1,VEGFR2,p-Akt,MAPK和STAT3的阳性反应,这表明信号通路已被激活.

结论:

VEGF信号通路被激活在大血管瘤中,类似于其他血管瘤.
抗VEGF治疗大血管肉瘤的疗效需要进一步研究.
这是第一个详细介绍大血管肉瘤中VEGFR免疫染色发现的报告,提供了对其分子特征的见解.

关键词:

血管肉瘤是一种血管肉瘤.案例报告案例报告上腺鼻 (maxillary sinus) 是一个上腺鼻.通过基因激活的蛋白质激酶.血管内皮生长因子血管内皮生长因子

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