老年疗法:基于衰老机制的药物和行为干预措施,以减少癌症的种族和民族差异
Jeanne S Mandelblatt1,2, Michael H Antoni3, Traci N Bethea2
1Georgetown Lombardi Institute for Cancer and Aging Research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Journal of the National Cancer Institute
|August 28, 2024
概括
健康的社会决定因素通过加速的生物衰老影响癌症差异. 针对衰老的新"老年疗法"可能会减少少数群体癌症幸存者的差异.
科学领域:
- 在瘤学瘤学.
- 老年学是一门学科.
- 健康差距 研究 研究 研究 研究
背景情况:
- 癌症发病率和死亡率的种族和民族差异与健康的社会决定因素有关.
- 健康的不利社会决定因素有助于加速生物衰老,特别是在少数群体中.
- 加快的衰老增加了癌症的风险,严重程度和影响结果.
研究的目的:
- 探索生物衰老在调解癌症差异中的作用.
- 提出新的"老年治疗" (针对衰老的干预措施),以减少癌症差异.
- 确定可针对性的衰老机制,以改善少数群体癌症幸存者的结果.
主要方法:
- 审查证据,将健康,生物衰老和癌症结果的社会决定因素联系起来.
- 概念框架提出老龄化作为差异的调解者.
- 讨论测试老年治疗药物的方法考虑.
主要成果:
- 对健康不利的社会决定因素的终身暴露加快了生物衰老.
- 加速衰老与癌症风险增加,早期发病和更糟糕的结局有关.
- 癌症及其治疗方法可能会加剧生物衰老,造成负面反循环.
结论:
- 生物衰老是导致癌症差异的一个关键机制.
- 老年治疗为减少少数群体癌症差异提供了一个有希望的途径.
- 解决加速衰老的结构性原因和确保公平获得干预措施至关重要.
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