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一个电化学CMOS生物传感器阵列使用仅相位调制,具有0.035%的相位误差和像素内平均值.

Aditi Jain, Saeromi Chung, Eliah Aronoff Spencer

    IEEE transactions on biomedical circuits and systems
    |August 28, 2024
    PubMed
    概括

    这项研究引入了一种新的CMOS生物传感器阵列,用于使用电化学阻抗光谱 (EIS) 快速,无标签的疾病检测. 高密度传感器实现了高灵敏度和可扩展性,用于点的护理应用.

    科学领域:

    • 生物医学工程 生物医学工程
    • 电气工程 电气工程
    • 传感器技术 传感器技术

    背景情况:

    • 护理点诊断需要敏感的,无标签的检测方法.
    • 电化学阻抗光谱 (EIS) 为疾病检测提供了高灵敏度.
    • 现有的CMOS生物传感器阵列在密度,可扩展性和读取效率方面面临挑战.

    研究的目的:

    • 开发一个高密度的16 × 20CMOS生物传感器阵列,用于无标签的疾病检测.
    • 实现一个可扩展的,主要是数字的读出电路与在像素的数字化.
    • 为了实现最先进的性能,仅在阶段性EIS测量中进行点护理应用.

    主要方法:

    • 设计了一个16 × 20 CMOS生物传感器阵列,使用极态,仅相 EIS 测量 (5 kHz - 1 MHz).
    • 集成了一个负载补偿的传 impedance 放大器和在 140 × 140 μm2 像素内主要是数字读出电路.
    • 采用像素内数字化和积累来增强信号噪声比 (SNR).

    主要成果:

    • 在100 kHz时使用一个不敏感的功率周期相位探测器实现了0.035%的rms相位误差.
    • 由于像素内积累,每增加10倍的读取时间就会增加10dB的SNR.

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  • 实现了最小的每像素面积之一,并集成了量子化.

    • 结论:

    • 开发的CMOS生物传感器阵列提供了一个高度敏感和可扩展的平台,用于快速检测疾病.
    • 这种设计使得在护理地点能够进行高效的无标签诊断.
    • 这项技术推进了综合生物传感,改善了SNR和减少了像素面积.