早期的营养不良暴露与成年期更高的骨质疏松风险有关:一项大规模的横截面研究
Hongbin Xu1,2,3,4, Haitao Zhang1,2,3,4, Remila Aimaiti5,6,7,8
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine.
International journal of surgery (London, England)
|August 28, 2024
概括
早期的营养不良暴露,特别是在胎儿和儿童阶段,显著增加了成年后患骨质疏松症的风险. 这种对骨健康的影响在女性和受教育程度较低或BMI较高的人群中更为明显.
科学领域:
- 营养流行病学 营养流行病学
- 骨健康和骨质疏松症研究研究
- 公共卫生和预防医学
背景情况:
- 关于早期营养不良对成人骨健康的长期影响的证据有限.
- 骨质疏松症和骨折构成重大公共卫生挑战,需要了解发育风险因素.
- 这项研究解决了不同发育阶段对营养不良暴露的知识差距及其与骨健康结果的联系.
研究的目的:
- 调查胎儿和儿童发育期间的营养不良暴露与成人骨质疏松症风险之间的关联.
- 检查早期营养不良与晚年骨折发生率之间的关系.
- 在一个独立的队列中验证发现,以确认早期营养不良对骨矿物质密度的影响.
主要方法:
- 使用来自中国社区骨质疏松症队列 (CCCO) 的数据进行横截面分析.
- 参与者分为未暴露,胎儿,早期,中期,晚期儿童和青少年暴露组.
- 用于评估骨质疏松症和骨折风险的多重后勤回归模型,在中国西北群体 (CNC) 中得到验证.
主要成果:
- 在胎儿和儿童阶段 (早期,中期,晚期) 的营养不良暴露与成人骨质疏松症的几率增加有关 (ORs从1.101到1.249不等).
- 儿童晚期营养不良暴露表明骨折风险增加 (OR: 1.155).
- 在受教育程度较低或超重/肥胖的人群中,发现了早期营养不良和骨质疏松症风险之间的显著相关性;CNC证实了这些发现.
结论:
- 早期的营养不良显著损害了成年人的骨健康,导致更容易患骨质疏松症.
- 这些有害影响在妇女,受教育程度较低的人,以及超重或肥胖的人群中尤为明显.
- 研究结果强调了胎儿和儿童发育期间适当营养对于长期骨完整性至关重要.
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