人类肠道微生物组中长寿种群的一致特征
Shu Chen1,2, Zhao Zhang3, Sanxin Liu4
1Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
Gut microbes
|August 28, 2024
概括
特定的肠道微生物,如艾森伯吉拉 (Eisenbergiella tayi) 和汉加特拉 (Hungatella hathewayi),在百岁以上的人群中经常被发现. 这些物种及其功能可能在人类的长寿和健康衰老中起因作用.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 遗传学 遗传学 是一个
背景情况:
- 百岁老人肠道微生物群的组成已得到充分研究,但特定物种的功能和与长寿的因果关系尚不清楚.
- 了解这些微生物特征对于衰老研究和健康跨度干预至关重要.
研究的目的:
- 识别与极端长寿相关的一致的肠道微生物物种和功能特征.
- 通过使用孟德尔随机化来调查肠道微生物与长寿相关特征之间的潜在因果关系.
主要方法:
- 在物种和功能层面上对八个长寿种群的便元基因组分析.
- 门德尔随机化 (MR) 分析以推断微生物种类和长寿特征之间的因果关系.
主要成果:
- 在长寿个体中持续丰富物种,如艾森伯吉拉泰伊,甲生物细菌smithii,Hungatella hathewayi和Desulfovibrio fairfieldensis.
- 确定了功能性作用,包括蛋白质N-糖化 (E. tayi),纯素稳态 (H. hathewayi) 和维生素K2生物合成 (D. fairfieldensis).
- 核磁共振分析显示,Hungatella和Desulfovibrio与父母的长寿和寿命之间存在正相关性.
结论:
- 确定了与长寿相关的肠道微生物特征,为微生物调节衰老提供了洞察力.
- 特定的微生物及其功能可能有助于长寿和预防与年龄相关的疾病.
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