大麻使用对甲状腺眼病和眼病的影响
Amanda M Zong1, Anne Barmettler
1Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, U.S.A.
Ophthalmic plastic and reconstructive surgery
|August 28, 2024
概括
大麻使用与患有自身免疫性甲状腺功能增强症的患者在诊断后一年内患甲状腺眼病 (TED) 的风险更高有关. 对于有效的TED管理策略,建议进行进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
背景情况:
- 甲状腺眼部疾病 (TED) 是一种影响眼睛的自身免疫性疾病,通常与甲状腺功能障碍症有关.
- 虽然吸烟是TED的已知风险因素,但大麻使用的影响仍然不清楚.
研究的目的:
- 在被诊断为自身免疫性甲状腺功能障碍症的患者中调查大麻使用和甲状腺眼病 (TED) 的发展之间的关联.
- 为了比较大麻使用者,尼古丁使用者和非使用者之间的TED演讲和治疗结果.
主要方法:
- 一项使用TrinetX电子健康记录的队列研究,从2003年12月到2023年12月.
- 倾向匹配用于控制自身免疫性甲状腺功能增强症患者的混变量.
- 对TED结局的相对风险在诊断后的6个月,1年和2年间隔计算.
主要成果:
- 与对照组 (n=18,093) 相比,大麻使用者 (n=783) 在一年内患上外眼瘤 (1.9倍) 和任何TED演讲 (1.6倍) 的可能性更高.
- 这些关联在1年时具有统计学意义,但在2年后没有持续.
- 大麻使用者通常更年轻,男性,黑人/非裔美国人,更容易患焦虑或抑郁症.
结论:
- 大麻使用者在诊断的第一年内显著增加了甲状腺眼睛疾病的风险.
- 这些发现表明大麻使用与TED早期演讲之间存在潜在联系.
- 需要进一步的研究,以指导在使用大麻的人群中TED的临床管理.
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