在癌症幸存者中,抑郁症状与第二次原发性癌症之间的关联:来自全国代表性研究的见解
Jie Zhou1, Xiaoxin Liu2, Xinjun Liang3
1Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, Hubei, China; Colorectal Cancer Clinical Research Center of Hubei Province, Wuhan 430079, Hubei, China; Colorectal Cancer Clinical Research Center of Wuhan, Wuhan 430079, Hubei, China.
General hospital psychiatry
|August 28, 2024
概括
抑郁症增加了癌症幸存者患第二种原发性癌症 (SPC) 的风险. 对于那些睡眠时间少于7小时的人来说,这种风险更高.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 癌症幸存者面临患第二种原发性癌症 (SPC) 的风险增加.
- 抑郁症状是癌症幸存者中常见的并发症.
- 在这个人群中,抑郁症状与SPC风险之间的关系需要进一步研究.
研究的目的:
- 在美国癌症幸存者中调查抑郁症状与患第二种原发性癌症 (SPC) 风险之间的关联.
主要方法:
- 采用美国癌症幸存者的2005-2018年国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 使用患者健康问卷9 (PHQ-9) 评估抑郁症状.
- 抑郁症状与SPC之间的关联分析使用多重逻辑回归,受限立方线 (RCS) 和灵敏度/子组分析.
主要成果:
- 癌症幸存者PHQ-9分数≥10的SPC风险显著增加 (OR=1.88,95%CI=1.20-2.89,p=0.005).癌症幸存者PHQ-9分数≥10的SPC风险显著增加 (OR=1.88,95%CI=1.20-2.89,p=0.005).
- RCS分析显示PHQ-9分数与SPC风险之间存在线性正相关性 (p = 0.017).
- 这种关联在睡眠时间小于7小时的幸存者中更为强烈 (相互作用的p = 0.036).
结论:
- 中度至重度的抑郁症状与癌症幸存者患第二种原发性癌症 (SPC) 的风险增加有关.
- 这种关联在经历睡眠时间不到7小时的个体中尤为明显.
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