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基于成像的身体组成异常与肝硬化患者的长期死亡率之间的关系

Wenhui Ren¹, Jiarui Zheng², Shuo Yang³

¹Department of Clinical Epidemiology, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing 100044, China.

European journal of radiology

|August 28, 2024

概括

身体构成的变化,包括肉类和骨髓硬化,显著影响肝硬化预后. 监测和管理这些变化可以改善患者的治疗结果,并减少与肝脏相关的死亡率.

科学领域:

肝病学肝病学是一种肝病学.
身体组成分析身体成分分析
预测生物标志物预测生物标志物

背景情况:

肝硬化与身体组成的改变有关,影响患者的预后.
身体组成的动态变化可能会影响肝硬化患者的结果.

研究的目的:

评估动态人体组成变化对肝硬化预后结果的影响.
为了确定身体组成特征作为肝脏相关死亡率的预测因素.

主要方法:

对158名肝硬化患者 (2018年1月 - 2023年8月) 的回顾性分析.
计算机断层扫描 (CT) 影像评估了骨肌肉质量,肌肉质量和脂肪度.
竞争风险模型和格雷测试分析了身体组成状况和与肝脏相关死亡率的动态变化.

主要成果:

萨尔科佩尼亚 (60.1%) 和骨髓炎 (43.0%) 是普遍存在的. 单独萨科佩尼亚就增加了死亡率 (P=0.006).
部和皮下脂肪率 (VSR),肉症和骨髓炎独立预测了与肝脏相关的死亡.
随访期间身体成分恶化显著增加死亡风险 (HR=7.63,P=0.036).

结论:

渐进的身体组成变化与肝硬化中与肝脏相关的死亡率有关.
骨肌肉和脂肪的管理对于改善肝硬化患者的预后至关重要.

关键词:

身体组成身体组成肝硬化是肝硬化的一种疾病.与肝脏相关的死亡率骨髓骨质炎 (Myosteatosis) 是一种骨髓骨质的疾病.预报预测预测预测萨尔科佩尼亚是什么意思萨尔科佩尼亚标本性肥胖症标本性肥胖症

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