高的饮食减轻了压力过载引起的心肺氧化应激,炎症和心力衰竭
Umesh Bhattarai1, Rui Xu1, Xiaochen He1
1Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
高的饮食通过减少炎症和氧化应激保护小鼠免受心力衰竭. 这种饮食干预提供了一种潜在的策略来对抗心力衰竭和相关的肺损伤.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 缺乏与凯珊病有关,这是一种心肌病,由于免疫细胞透导致心力衰竭 (HF).
- 系统性过载可以诱导心肺炎和HF.
研究的目的:
- 调查高饮食是否可以减轻因缩过载引起的炎症和HF.
- 评估高对心脏和肺重塑的影响.
主要方法:
- 雄性小鼠经历了横向大动脉收缩 (TAC),以诱导缩过载.
- 给小鼠食的是高或正常的饮食.
- 分析了心脏和肺氧化应激,炎症,功能障碍和重塑标志物.
主要成果:
- 高的饮食可以防止TAC诱导的左心室缩,功能障碍和增加肺/右心室体重.
- 它减少了心脏和肺炎,纤维化和氧化应激标志物 (ROS,4-HNE,3-NT).
- 高还减弱了免疫细胞的激活,包括巨细胞和T细胞.
结论:
- 高饮食有效减轻心脏氧化应激,炎症和HF发展.
- 它还减轻了随之而来的肺炎和缩压过载后的重塑.
- 饮食中的代表了预防或治疗心力衰竭的有希望的治疗途径.
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