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在晚期发病与成人发病多发性硬化症的认知结果

Ana Inês Oliveira¹, Isabel Rovisco Monteiro², Alexandre Roldão Alferes²

¹Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Multiple sclerosis and related disorders

|August 28, 2024

概括

晚期发病的多发性硬化症 (MS) 与成人发病的MS相比,与较差的认知功能有关,特别是与血管风险因素有关. 对LOMS患者来说,风险因素和认知活动的管理至关重要.

科学领域:

神经学神经学
神经科学是一个神经科学.
认知科学认知科学

背景情况:

在患有多发性硬化症 (MS) 的老年人中,认知障碍越来越被认可.
确切的原因 - - 慢性疾病的进展与与年龄相关的变化 - - 尚不清楚.
晚发性多发性硬化 (LOMS) 提供了一个独特的机会来研究MS中与年龄相关的认知衰退.

研究的目的:

为了比较晚发性MS (LOMS) 与成人发性MS (AOMS) 患者的经典和社会认知表现.
研究年龄和疾病持续时间对MS认知结果的影响.
确定与LOMS认知缺陷相关的因素.

主要方法:

一项横截面研究,将27名LOMS患者 (>50岁开始) 与27名年龄和疾病持续时间匹配的AOMS患者进行比较.
使用多发性硬化症简要国际认知评估 (BICAMS) 和修订的"阅读眼睛中的思想"测试 (RMET) 评估认知功能.
收集和分析了包括血管风险因素 (VRF) 在内的临床和人口统计数据.

主要成果:

与AOMS相比,LOMS患者在经典和社会认知方面表现较差,即使对年龄和疾病持续时间进行控制.
在大多数领域 (不包括口头记忆) 中,发现疾病发病年龄和认知表现之间存在显著的负相关性.
血管风险因素 (VRF) 的存在与信息处理速度 (SDMT) 减慢和社会认知能力 (RMET) 降低有关.

结论:

晚年出现的MS与认知功能恶化有关,可能是由于老化大脑的神经可塑性降低.
与AOMS患者相比,LOMS患者的认知结果较差,特别是当血管风险因素存在时.
医疗保健提供者和患者应优先考虑LOMS患者的认知刺激,VRF管理和社会参与.

关键词:

成年人开始的开始.认知障碍认知障碍是一种认知障碍.晚期发病晚期发病多发性硬化症是多发性硬化症.社会的认知社会认知.思想理论思想理论

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