特里弗卢诺米德,认知和MRI:一项纵向研究
1University of Strasbourg, Strasbourg, Biopathology of Myelin, Neuroprotection and Therapeutic Strategies, INSERM U1119, Strasbourg, France.
Multiple sclerosis and related disorders
|August 28, 2024
概括
在复发性缓解性多发性硬化症 (RRMS) 治疗teriflunomide (TRF) 治疗两年后改善了长期口语记忆和抑制. 磁力共振成像数据表明,认知能力的提高与白质体积的变化之间存在相关性,特别是在大脑体中.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 认知障碍是多发性硬化症 (MS) 的常见和致残症状.
- 特里弗卢诺胺 (TRF) 是一种改变多发性硬化症的疗法,但其对认知的影响尚未得到充分证实.
- 了解TRF对认知功能和相关的神经成像变化的影响对于MS管理至关重要.
研究的目的:
- 调查特里弗卢诺米德 (TRF) 对复发性复发性多发性硬化症 (RRMS) 综合认知功能的影响.
- 在两年TRF治疗后,探索认知表现和MRI衍生的全球和焦点大脑体积之间的相关性.
- 区分TRF对具有或没有基线认知障碍的RRMS患者认知功能的影响.
主要方法:
- 24名RRMS患者在基线和两年TRF治疗后被评估.
- 使用BCcogSEP电池评估认知功能,包括选择性提醒测试 (SRT) 和GoNoGo任务.
- 核磁共振成像数据,包括体体积和脑体积百分比变化,与认知测试表现相关.
主要成果:
- 两年后,在SRT学习,延迟回忆和GoNoGo任务中观察到显著改善.
- 体体积与SRT总回忆性能正相关.
- 与没有认知障碍的患者相比,认知障碍患者在白质体积和脑体积百分比变化方面表现出显著差异.
结论:
- 泰里弗卢诺米德 (TRF) 治疗对RRMS的认知功能产生了积极影响,特别是增强了长期的口头记忆和抑制.
- 神经成像发现表明认知改善与全球和焦点白质体积的变化之间存在联系,特别是体.
- 这些结果突出了TRF在解决MS认知缺陷方面的潜力,并强调了白质完整性在大脑可塑性中的作用.
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