COVID-19和心肌损伤:针对潜在的新疗法的高生物标志物
Pengyang Li1, Qun Chen1, Ion S Jovin1
1Virginia Commonwealth University, Richmond VA; McGuire VA Medical Center, Richmond VA.
Clinics (Sao Paulo, Brazil)
|August 28, 2024
概括
在住院患者中,COVID-19是导致热波水平升高的重要原因. 年龄,热素和C反应蛋白水平预测结果不佳,建议针对心肌损伤进行向治疗.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 由于COVID-19的流行,住院患者的心肌损伤的增加.
- 增加的氧化应激和炎症生物标志物与COVID-19相关的心肌损伤有关.
- 针对这些生物标志物的新疗法可能会改善结果.
研究的目的:
- 调查COVID-19的流行率作为心肌损伤患者的初级诊断.
- 为了确定COVID-19患者中死亡率的预测因素,这些患者血红素水平升高.
- 探索心脏生物标志物在COVID-19相关心肌损伤中的作用.
主要方法:
- 分析了2021年1月1日至12月31日期间的急诊室患者的热素测定结果.
- ICD-10诊断的分类和生物标志物升高的记录,用于高托罗邦素的入院患者.
- 确定COVID-19患者6个月随访期间死亡的独立预测因素.
主要成果:
- COVID-19是10%的心肌损伤患者的首要诊断.
- 在COVID-19患者中,死亡的独立预测因素包括年龄,峰值热素水平和峰值C反应蛋白 (CRP) 水平.
- 患有心肌损伤的COVID-19患者中有42%在6个月内死亡.
结论:
- 新诊断的COVID-19是没有1型心肌梗塞的住院患者中高托罗的常见原因.
- 年龄,峰值热素和峰值CRP水平是不良结果的独立预测因素.
- 用抗氧化剂或抗炎疗法向心脏生物标志物可能是有益的.
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